Regional Italian comfort food is paired with an eclectic American-Italian wine list, old-school cocktails and a roster of small-production beers at Via Ventuno, a midpriced redo of Jerry Kleiner's Room 21 in the South Loop; carryovers include the wild wallpaper and vast landscaped courtyard (growing herbs for the kitchen), while new elements include an antipasti/salumi station and retro touches like red velvet banquettes and a padded bar.
2110 S. Wabash Ave.; 312-328-1198; reserve online